Rheumatoid arthritis can be cured Now - A new research - Seeker's Thoughts

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Rheumatoid arthritis can be cured Now - A new research

Rheumatoid arthritis is a chronic inflammatory disorder. It’s an autoimmune disorder, rheumatoid arthritis happens when the immunity system mistakenly attacks its own body’s tissue.
picture credits - WebMD

This disorder can affect more than just human joints. It’s seen in some people, this condition can damage a whole variety of body systems, including the skin, eyes, lungs, heart, and blood vessels.

According to a new study, researchers discovered a new type of cells could one day help rheumatoid arthritis patients predict the onset of painful flare-ups of the disease. The study published in the New England journal of medicine.

What type of cell scientists has found?

According to scientists that the never-been-seen cell type appeared in patients’ blood a week before their symptoms flared up.

They named these cells pro-inflammatory, mesenchymal, or PRIME, cells.

Experts say this discovery could potentially lead to a future blood test that could warn patients of coming flare.

What is a flare?

Periods of increased disease activity, called flares, alternate with periods of relative remission – when the swelling and pain fade or disappear. Over time, rheumatoid arthritis can cause joints to deform and shift out of place.

How painful and can impact other body organs?

It can cause painful swelling that can eventually result in bone erosion and joint deformity.

The inflammation which is associated with rheumatoid arthritis is what can damage other parts of the body as well.

There are new types of medications and diagnosis have improved treatment options dramatically severe rheumatoid arthritis can still cause physical disabilities.

How can you detect the disease?

In early-stage rheumatoid arthritis tends to affect your smaller joints first – particularly the joints attach your finger to your hands and your toes to your feet.

However, when the disease starts growing, its symptoms often spread to the wrists, knees, ankles, elbows, hips, and shoulders. In some cases, symptoms occur in the same joints on both sides of the body.

Other symptoms of rheumatoid arthritis

Common symptoms include – Tender, warm, swollen joints, joint stiffness that is usually worse in the mornings, and after inactivity. Fatigue, fever, and loss of appetite.

What is the potential of the newly discovered cell to cure rheumatoid arthritis?

The researchers believe, that the PRIME cells could also be a potential target for drugs. This cell type may play a role in attacking healthy tissue.

One of the Researchers Darnell says, “We could figure out a way to block it so it doesn’t get into the joint. And maybe you wouldn’t get a flare”. So clearly it has a potential therapeutic value to pursue.

How did they discover it?

Four patients sent weekly finger stick blood samples to the lab for over one to four years. The patients also kept a diary documenting their symptoms and visited the clinic once a month.

Then after that researchers sequenced the blood samples to observe gene activity, using information from the patient's clinical visits, symptoms diaries and blood samples, and what they found that the PRIME cells appeared in the blood one week before a flare, the presence of the cells was also confirmed in blood samples from 19 additional patients. But these patients didn’t keep symptoms diaries, so it still unclear when the cells appeared relative to a flare-up.


According to Diane Horowitz, these findings benefit both scientists and patients.

Scientists say, it will help us to find out the pathway that occurs before a flare which will help us with flare identification, medication options, treatments, that whole pathway, who was not involved with the new study.

The research provides insights into what’s happening on the cellular level that may induce arthritis. And therefore, once we know about those cells, we can then find ways to develop the treatments that will target them, and prevent the flare.

They also said, it will also be interesting for patients if there’s a way that they can predict when they’re going to have a flare, and they can treat it earlier and take care of a flare before it actually occurs.

The expert also noted that while the new findings are exciting, much more research is needed to fully understand the role PRIME cells play in rheumatoid arthritis. There’s way more that needs to be done with it before it can become anything clinically applicable for patients in this study.

It is a promising research study that’s coming out, and the ability to do a broader, a more longitudinal study would really make a difference and give hope.

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