Pfizer vs AstraZeneca - which one is most effective? - Seeker's Thoughts

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Pfizer vs AstraZeneca - which one is most effective?

 According to the new study by Public Health England, both Pfizer and AstraZeneca vaccines are extremely effective at protecting people from the Covid -19 strain that was firstly found in India.

According to the new analysis carried out between 5 April and 16 may found the Pfizer vaccine was 88% effective against the Indian variant two weeks after a second dose, compared with 93% effectiveness against the kent variant. On the other hand, the AstraZeneca vaccine had been found 60% effective comparatively with 66% against the kent variant over the same period.

According to the data, it takes a bit longer for the AstraZeneca vaccine to reach maximum 

effectiveness. Clearly, the second jab is crucial for the strongest possible protection against the virus and its variants.

How does the AstraZeneca vaccine work?

AstraZeneca vaccine uses adenovirus-vectored technology, which is a harmless, modified version of a common cold virus that is usually found and spreads among chimpanzees. This altered virus cannot make humans sick. However, it carries a gene for the coronavirus' spike protein, a particular portion of the virus triggers an immune response that allows the immune system to produce antibodies that work against novel coronavirus, that teaches the human body how to respond when it attacks.

According to Anna Durbin, who is an infectious disease expert at John Hopkins Medicine, "this is the beautiful genetic material of the spike protein coming into the body like it would if It were part of the SARS-CoV-2 virus," however there will be no danger of catching the virus.

How does the Pfizer vaccine work?

According to the study, the Pfizer vaccine is 88% effective against the B.1.617.2 Indian strain after getting Pfizer's two weeks after the second dose. Pfizer vaccine had been 93% effective against the UK's variant. That is known as B.1.1.7, two weeks after the second dose.

The vaccine is composed of nucleoside-modified mRNA(modRNA) encoding a mutated form of the full-length spike protein of SARS-CoV2, which is encapsulated in lipid nanoparticles. The vaccination requires two doses given three weeks apart.

According to the data, the importance of getting both doses of the vaccine and effective results were measured two weeks after a second dose. Study results show the effectiveness after one vaccine was remarkably lower with the India variant. The first dose was only 33.5% effective against the India sub-variant (B.1.617.2) compared to 51.1% effectiveness against the UK variant (B.1.1.7).

According to the researchers, the results of both vaccines should offer even more protection against hospital admissions and deaths.

This analysis is based on a study carried out on people of all ages, and about 1,054 people participated in the study. The study had been covered the period when the Indian strain erupted. These were confirmed as having the variant through genome sequencing.


Therefore vaccines aren't totally a lifesaver; prevention is better than cure, wearing a mask, hand-washing, and social distancing to work as effectively as possible. CDC stated that no matter which vaccines become available at first place. People must be confident in its ability to protect them from the virus, as long as people continue being cautious until the rise in case, hospitalizations and death are significantly reduced nationwide.

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